Volume 1 · Attributed research edition · Microbes and cancer

A distinct Fusobacterium nucleatum clade dominates the colorectal cancer niche

Martha Zepeda-Rivera; Samuel S. Minot; Heather Bouzek; Hanrui Wu; Aitor Blanco-Míguez; Paolo Manghi; Dakota S. Jones; Kaitlyn D. LaCourse; Ying Wu; Elsa F. McMahon; Soon-Nang Park; Yun K. Lim; Andrew G. Kempchinsky; Amy D. Willis; Sean L. Cotton; Susan C. Yost; Ewa Sicinska; Joong-Ki Kook; Floyd E. Dewhirst; Nicola Segata; Susan Bullman; Christopher D. Johnston

Nature · 2024-03-20 · Microbial genomics and experimental research

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Springer Science and Business Media LLC · Version of record, publisher-supplied full-text XML archived in Europe PMC; correction notices linked where present.

DOI: 10.1038/s41586-024-07182-w

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https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Tumor enrichment, genomic distinctions and experimental models do not establish that every oral F. nucleatum strain causes cancer. Findings do not validate a salivary cancer-screening test or demonstrate that eliminating oral bacteria prevents colorectal cancer. Standard screening remains necessary.

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Verification date: 2026-10-22

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