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License evidence Interpretation limitsTrials assess surrogate markers rather than demonstrating fewer heart attacks, strokes or deaths. Certainty varies by outcome and several lipid, inflammatory and vascular measures did not improve. A linked publisher correction has been retained and must be consulted with this edition.
Publication status checkNo retraction notice found in the checked sources; corrections linked. Publisher-supplied full-text XML (article title/type and related notices), Europe PMC core publication types, and publisher-deposited Crossref update-to/updated-by/relation metadata checked on 2026-10-22. Bounded record checks are not a comprehensive guarantee of article integrity; Crossref and repository metadata may be incomplete or lag publisher updates.
Correction replaces the funding grant number KY017005 with 2016059.
Verification date: 2026-10-22
Edition changesNarrative text with normalized layout; original references retained. Figures, tables, displayed equations and separately licensed third-party material are omitted. Consult the original for definitive pagination and visual evidence.
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8,653 words in this edition.