The salivary microbiome as a diagnostic biomarker of periodontitis: a 16S multi-batch study before and after the removal of batch effects

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DOI: 10.3389/fcimb.2024.1405699

Copyright © 2024 Regueira-Iglesias, Suárez-Rodríguez, Blanco-Pintos, Relvas, Alonso-Sampedro, Balsa-Castro and Tomás

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Diagnostic performance depends on sample selection, sequencing, batch adjustment and validation design. Discrimination between study groups does not establish clinical utility, prospective performance, commercial-test equivalence or systemic-disease prediction. The models should not replace periodontal examination.

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Verification date: 2026-10-22

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