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Parenting Journal · Volume 2 · Issue 1 · Licensed source edition

The Interaction Effect of Parental Rejection and Oxytocin Receptor Gene Polymorphism on Depression: A Cross-Cultural Study in Non-Clinical Samples

Originally published 2022-05-04 · International Journal of Environmental Research and Public Health
Multidisciplinary Digital Publishing Institute (MDPI) · DOI 10.3390/ijerph19095566 ↗

RespectObservational studyCC BY 4.0
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Editorial reading guide · Respect

What might a young adult remember differently about the responses of two caregivers?

Participants reported perceived rejection separately for mothers and fathers in a small cross-cultural sample.

Who was studied?

One hundred and thirty-three young adults from Italy and Japan.

Age / stage: Ages 18–27

Read with three questions

  1. How does the small sample limit interpretation of the gene-by-environment comparison?
  2. Which parts of the interaction were directly observed and which were inferred or reported?
  3. What might a young adult remember differently about the responses of two caregivers?

Keep the limits in view

The study measures behaviors or experiences in a particular sample and setting. It cannot establish the effect of changing a response in an individual family.

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Attribution & reuse

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Original authorship, publication date, journal and DOI are preserved. This issue’s TRICK placement and reading questions are editorial additions, not claims made by the original authors.

Vincenzo Paolo Senese; Kazuyuki Shinohara; Paola Venuti; Marc H Bornstein; Vittorio Rosanio; Carla Nasti; Michelle Jin-Yee Neoh; Marzia Maresca; Gianluca Esposito; Paul B Tchounwou (2022). The Interaction Effect of Parental Rejection and Oxytocin Receptor Gene Polymorphism on Depression: A Cross-Cultural Study in Non-Clinical Samples International Journal of Environmental Research and Public Health. https://doi.org/10.3390/ijerph19095566

Permissions checked against the saved article notice; repository publication notices screened 2026-11-04. This is not a new peer-review decision. The source authors and publishers are not represented as endorsing this issue.