The Research University · Volume 1 · 2026
Where dental innovation meets whole-person health. Science, technology and clinical judgment for a more precise, preventive future.
25 attributed Creative Commons research editions · One founding editorial synthesis · A paper agent for every article
The launch feature · Dr. Edward Zuckerberg’s talk
Dr. Edward Zuckerberg’s conference talk connects the oral microbiome with a wider innovation agenda: salivary diagnostics, personalized home care, optical imaging, robotics, sleep health and the operation of dental practices. This launch feature presents an edited thematic account of the supplied transcript and an independent appraisal of selected evidence. It distinguishes oral–systemic associations from demonstrated treatment benefit, diagnostic performance from clinical usefulness, and investigational technologies from authorized products. The resulting framework connects each innovation to a clinical decision, a responsible owner, an evidence milestone and a stopping condition. Dentistry’s forward-looking opportunity is not simply to generate more data, but to make prevention, coordination and accountable care more effective.
Volume 1 · The future of oral health
25 of 25 research editions. Original authors, journals, dates and DOIs are preserved.
Metabolic health · Randomized-trial network meta-analysis
Xuejie Xie; Jun Xu; Yiming Li; et al.
Acta Odontologica Scandinavica · 2025-05-13 · CC BY 4.0
Compares adjuncts to nonsurgical periodontal treatment for adults with type 2 diabetes, including periodontal and glycemic outcomes.
Metabolic health · Overview of systematic reviews
Nansi López-Valverde; José Antonio Blanco Rueda
Healthcare · 2024-09-14 · CC BY 4.0
Examines the periodontal-treatment and diabetes literature while explicitly evaluating review quality and bias.
Metabolic health · Register-based observational cohort
Anna Trullenque-Eriksson; Cristiano Tomasi; Katarina Eeg-Olofsson; et al.
BMJ Open · 2024-07-04 · CC BY 4.0
Large Swedish linked registers assess diabetes, periodontitis and complications, including informative null cardiovascular findings.
Metabolic health · Systematic review and meta-analysis of observational studies
Dan Zhao; Yangyang Sun; Xin Li; et al.
Healthcare · 2023-09-28 · CC BY 4.0
Examines HbA1c differences among people without diagnosed diabetes and the potential role of dental settings in referral for glycemic assessment.
Cardiovascular health · Systematic review and meta-analysis of randomized trials
Rijing Meng; Jialei Xu; Chenrui Fan; et al.
BMC Oral Health · 2024-06-14 · CC BY 4.0
Separates changes in cardiovascular risk markers after periodontal treatment from claims about clinical cardiovascular events.
Cardiovascular health · Prospective population-based cohort
Christiane Pink; Birte Holtfreter; Henry Völzke; et al.
BMC Medicine · 2023-11-13 · CC BY 4.0
Tests joint associations of periodontal disease and systemic inflammation with long-term mortality.
Cardiovascular health · Prospective cohort with long follow-up
Georgios N. Antonoglou; Mario Romandini; Jukka H. Meurman; et al.
Journal of Periodontal Research · 2022-10-25 · CC BY 4.0
Distinguishes edentulism from periodontitis when considering oral health and cardiovascular mortality.
Cardiovascular health · Systematic review and meta-analysis
Jingzhe Lyu; Yiyao Zhang; Run Zhou; et al.
PLOS ONE · 2024-09-19 · CC BY 4.0
Evaluates endothelial-function outcomes following periodontal treatment.
Brain and cognition · Prospective cohort
Dominic N Farsi; Rena Abadalkareem; Gerry J Linden; et al.
Journal of Alzheimer's Disease · 2025-12-12 · CC BY 4.0
Provides a 15-year study with a null association between clinical periodontitis and later cognitive impairment or dementia, helping balance the volume.
Brain and cognition · Administrative-database case-control study
Hui-Ling Chen; Dai-Rong Wu; Jhih-Jhen Chen; et al.
BMC Oral Health · 2023-12-06 · CC BY 4.0
Examines associations between dental treatment histories and dementia diagnoses in Taiwan.
Brain and cognition · Meta-analysis
Haiying Guo; Shuli Chang; Xiaoqin Pi; et al.
International Journal of Environmental Research and Public Health · 2021-06-25 · CC BY 4.0
Synthesizes the association between periodontal disease, dementia and cognitive impairment.
Brain and cognition · Narrative review
Mark I Ryder
Journal of Periodontology · 2020-08-06 · CC BY 4.0
Reviews Porphyromonas gingivalis, gingipains and possible mechanisms linking periodontal and Alzheimer pathology.
Microbes and cancer · Microbial genomics and experimental research
Martha Zepeda-Rivera; Samuel S. Minot; Heather Bouzek; et al.
Nature · 2024-03-20 · CC BY 4.0
Resolves Fusobacterium nucleatum at clade level in colorectal cancer, showing why species-level claims may be too broad.
Microbes and cancer · Experimental and translational research
Lishay Parhi; Tamar Alon-Maimon; Asaf Sol; et al.
Nature Communications · 2020-06-26 · CC BY 4.0
Studies mechanisms of Fusobacterium nucleatum localization and tumor progression in breast-cancer models.
Microbes and cancer · Experimental and translational research
Huiyuan Zhu; Man Li; Dexi Bi; et al.
Nature Communications · 2024-02-24 · CC BY 4.0
Links F. nucleatum effects to KRAS genotype and microbial ecology in colorectal cancer models.
Microbes and cancer · Structural and molecular research
Felix Schöpf; Gian L Marongiu; Klaudia Milaj; et al.
Nature Communications · 2025-08-29 · CC BY 4.0
Defines Fap2 interactions with cancer-cell and immune-cell receptors, providing a mechanistic target for future investigation.
Salivary diagnostics · Diagnostic microbiome model study
Alba Regueira-Iglesias; Berta Suárez-Rodríguez; Triana Blanco-Pintos; et al.
Frontiers in Cellular and Infection Microbiology · 2024-07-12 · CC BY 4.0
Demonstrates how batch effects alter salivary microbiome classifiers for periodontitis.
Salivary diagnostics · Repeated-measures biomarker study
Amanda Carolina Souza Delfino Rocha; Renata Klemp Orlandini; Ana Carolina Fragoso Motta; et al.
Frontiers in Dental Medicine · 2024-03-18 · CC BY 4.0
Examines within-day and between-day variation in salivary inflammatory analytes and the effect of eating and brushing.
Salivary diagnostics · Systematic review of diagnostic proteomics
Hongying Hu; Wai Keung Leung
International Journal of Molecular Sciences · 2023-09-27 · CC BY 4.0
Reviews mass-spectrometry salivary biomarker discovery and the limited replication of candidate proteins.
Salivary diagnostics · Diagnostic case-control study
Zainab J. Raheem; Hayder Raad Abdulbaqi
International Journal of Dentistry · 2024-10-15 · CC BY 4.0
Tests salivary IL-1β, IL-10 and their ratio against clinical periodontal groups.
Microbiome and prevention · Dietary-intervention microbiome analysis
Anni Vanhatalo; Joanna E L'Heureux; James Kelly; et al.
Redox Biology · 2021-03-05 · CC BY 4.0
Explores nitrate-sensitive oral microbial networks and cardiovascular or cognitive indices in older adults.
Microbiome and prevention · In vitro biofilm experiment
B. T. Rosier; E. Buetas; E. M. Moya-Gonzalvez; et al.
Scientific Reports · 2020-07-30 · CC BY 4.0
Tests nitrate effects on oral biofilms grown from saliva of healthy donors.
Microbiome and prevention · Randomized crossover dietary trial
Rebeka Fejes; Joana Séneca; Petra Pjevac; et al.
Molecular Nutrition & Food Research · 2025-06-16 · CC BY 4.0
Studies oral and intestinal microbiome responses to nitrate-rich beetroot juice in older adults with treated hypertension.
Pregnancy and oral health · Systematic review and meta-analysis of observational studies
Quynh-Anh Le; Rahena Akhter; Kimberly Mathieu Coulton; et al.
Maternal and Child Health Journal · 2022-10-08 · CC BY 4.0
Synthesizes periodontitis and preeclampsia associations across case-control and cohort studies.
Pregnancy and oral health · Review
Anna Starzyńska; Piotr Wychowański; Maciej Nowak; et al.
International Journal of Molecular Sciences · 2022-02-24 · CC BY 4.0
Examines proposed relationships between maternal periodontitis and offspring systemic health.